The present study pertains to the development of Gastroretentive drug delivery systems (GRDDS) of Ketoconazole, which is having narrow absorption window in gastrointestinal tract. The two different floating drug delivery systems were developed for controlled drug delivery of Ketoconazole in stomach. A 32 factorial design was used in formulating the buoyant capsule with hydroxypropyl methyl cellulose (HPMC K15 M) and lactose as independent variables. Floating time, swelling index, drug release were the three dependent variables. The floating tablet formulation was developed by taking the optimized capsule formulation as base point. Sodium bicarbonate was used as gas forming agent and citric acid was added to counteract the neutralizing effect of sodium bicarbonate in stomach and to prolong the in vivo gastric retention. These tablets were evaluated for floating lag time, in vitro floating time and drug release properties. The in vivo buoyancy time for tablets and capsules were evaluated by X-ray studies. In vivo study showed that the optimum tablet and capsule formulation were retained in stomach for more than eight hours. The percent drug release of capsule formulation was found to be 80.33% and that of tablet formulation was found to be 80.16% in 8 hours which serves the purpose of developing a gastro retentive formulation.
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